Determinants of BH3 Binding Specificity for Mcl-1 versus BcI-x[subscript L]

Determinants of BH3 Binding Specificity for Mcl-1 versus BcI-x[subscript L]

Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3 (Bcl-2-homology-3)-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by bindi...

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Main Authors: Dutta, Sanjib (Contributor), Gulla, Stefano (Contributor), Fire, Emiko (Contributor), Keating, Amy E. (Contributor), Chen, T. Scott (Author), Grant, Robert A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Chen, Tsan Chou Scott (Contributor), Grant, Robert A. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2012-09-28T14:10:16Z.
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