Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential

Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential

Clinical and preclinical applications of human hematopoietic stem cells (HSCs) are often limited by scarcity of cells. Expanding human HSCs to increase their numbers while maintaining their stem cell properties has therefore become an important area of research. Here, we report a robust HSC cocultur...

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Bibliographic Details
Main Authors: Drake, Adam (Contributor), Chen, Qingfeng (Contributor), Dong, Di (Contributor), Leskov, Ilya B. (Contributor), Fragoso, Maria F. (Contributor), Li, Yan (Contributor), Iliopoulou, Bettina P. (Contributor), Hwang, William (Author), Lodish, Harvey F. (Contributor), Chen, Jianzhu (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Mary Ann Liebert, 2012-09-12T13:28:55Z.
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