Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RNA editing and function. Among many forms of nucleic acid damage, deamination arises from several unrelat...

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Bibliographic Details
Main Authors: Pang, Bo (Contributor), McFaline, Jose Luis (Contributor), Burgis, Nicholas E. (Author), Taghizadeh, Koli (Contributor), Sullivan, Matthew R. (Contributor), Elmquist, C. Eric (Contributor), Cunningham, Richard P. (Author), Dedon, Peter C. (Contributor), Dong, Min 1968- (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Dong, Min (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2012-09-05T19:30:39Z.
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