Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the multi...

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Main Authors: Lin, Wenchu (Author), Cao, Jian (Author), Liu, Jiayun (Author), Beshiri, Michael L. (Author), Fujiwara, Yuko (Author), Francis, Joshua M. (Author), Cherniack, Andrew D. (Author), Geisen, Christoph (Author), Blair, Lauren P. (Author), Zou, Mike R. (Author), Shen, Xiaohua (Author), Liu, Zongzhi (Author), Grisanzio, Chiara (Author), Watanabe, Hideo (Author), Minamishima, Yoji Andrew (Author), Zhang, Qing (Author), Kulkarni, Rohit N. (Author), Signoretti, Sabina (Author), Rodig, Scott J. (Author), Bronson, Roderick T. (Author), Orkin, Stuart H. (Author), Tuck, David P. (Author), Benevolenskaya, Elizaveta V. (Author), Kawamori, Dan (Author), Meyerson, Matthew L. (Contributor), Kaelin Jr., William G. (Author), Qin, Yan (Author)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2012-04-20T15:34:27Z.
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