Rational Design of New Binding Specificity by Simultaneous Mutagenesis of Calmodulin and a Target Peptide

Rational Design of New Binding Specificity by Simultaneous Mutagenesis of Calmodulin and a Target Peptide

Calcium-saturated calmodulin (CaM) binds and influences the activity of a varied collection of target proteins in most cells. This promiscuity underlies the role of CaM as a shared participant in calcium-dependent signal transduction pathways but imposes a handicap on popular CaM-based calcium biose...

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Bibliographic Details
Main Authors: Green, David F. (Contributor), Dennis, Andrew T. (Contributor), Fam, Peter S. (Contributor), Tidor, Bruce (Contributor), Jasanoff, Alan Pradip (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Nuclear Science and Engineering (Contributor), Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2012-04-12T17:34:36Z.
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