Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

Multitarget compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms of a particular combination of relatively more spec...

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Bibliographic Details
Main Authors: Wands, Jack R. (Author), Cosgrove, Benjamin D. (Contributor), Hemann, Michael (Contributor), Pritchard, Justin R. (Author), Griffith, Linda G (Author), Lauffenburger, Douglas A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Lauffenburger, Douglas A. (Contributor), Pritchard, Justin Robert (Contributor), Griffith, Linda G. (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2011-11-16T22:45:55Z.
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