Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

The development of molecular probes that allow in vivo imaging of neural signaling processes with high temporal and spatial resolution remains challenging. Here we applied directed evolution techniques to create magnetic resonance imaging (MRI) contrast agents sensitive to the neurotransmitter dopam...

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Main Authors: Shapiro, Mikhail G. (Contributor), Westmeyer, Gil Gregor (Contributor), Szablowski, Jerzy O. (Contributor), Küster, Benedict (Contributor), Shah, Ameer (Contributor), Langer, Robert (Contributor), Jasanoff, Alan Pradip (Contributor), Romero, Philip A. (Author), Arnold, Frances H. (Author), Otey, Christopher R. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Nuclear Science and Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Company, 2011-10-28T18:16:10Z.
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