A DinB variant reveals diverse physiological consequences of incomplete extension by a Y-family DNA polymerase

A DinB variant reveals diverse physiological consequences of incomplete extension by a Y-family DNA polymerase

The only Y-family DNA polymerase conserved among all domains of life, DinB and its mammalian ortholog pol κ, catalyzes proficient bypass of damaged DNA in translesion synthesis (TLS). Y-family DNA polymerases, including DinB, have been implicated in diverse biological phenomena ranging from adaptive...

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Bibliographic Details
Main Authors: Jarosz, Daniel F. (Contributor), Cohen, Susan E. (Contributor), Delaney, James C. (Contributor), Essigmann, John M. (Contributor), Walker, Graham C. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-10-03T16:20:19Z.
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