Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
The dense collagen network in tumors significantly reduces the penetration and efficacy of nanotherapeutics. We tested whether losartan-a clinically approved angiotensin II receptor antagonist with noted antifibrotic activity-can enhance the penetration and efficacy of nanomedicine. We found that lo...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences (U.S.),
2011-09-23T18:46:47Z.
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| Subjects: | |
| Online Access: | Get fulltext |