Autocrine-controlled formation and function of tissue-like aggregates by hepatocytes in micropatterned hydrogel arrays

Autocrine-controlled formation and function of tissue-like aggregates by hepatocytes in micropatterned hydrogel arrays

The liver carries out a variety of essential functions regulated in part by autocrine signaling, including hepatocyte-produced growth factors and extracellular matrix (ECM). The local concentrations of autocrine factors are governed by a balance between receptor-mediated binding at the cell surface...

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Main Authors: Williams, Courtney M. (Contributor), Mehta, Geeta (Contributor), Peyton, Shelly R. (Contributor), Zeiger, Adam Scott (Contributor), Van Vliet, Krystyn J. (Contributor), Griffith, Linda G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Gynepathology Research (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Mary Ann Liebert, Inc., 2011-07-14T14:03:13Z.
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