A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint

DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage checkpoints has been studied extensively, molecular...

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Bibliographic Details
Main Authors: Yaffe, Michael B. (Contributor), Brummelkamp, Thijn R. (Contributor), Reinhardt, Hans (Contributor), Ostheimer, Gerard (Contributor), Gardino, Alexandra Kate (Contributor), van Vugt, Marcel A. T. M. (Contributor), Smerdon, Stephen J. (Author), Carr, Steven A. (Author), Lewis, Timothy A. (Author), Pawson, Tony (Author), Li, Jeijin (Author), Keezer, Susan M. (Author), Miao, Hua (Author), Tan, Chris S. (Author), Ong, Shao-En (Author), Linding, Rune (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-05-28T20:09:02Z.
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