Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein

Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein

We analyzed the relationship between pathogenic protein expression and perturbations to brain anatomy and physiology in a genetic model of prion disease. In this model, the mouse line 1D4, neuropathology is promoted by accumulation of a cytosolic form of the prion protein (cyPrP). CyPrP distribution...

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Bibliographic Details
Main Authors: Lindquist, Susan (Contributor), Jasanoff, Alan Pradip (Contributor), Ma, Jiyan (Author), Wang, Xinhe (Author), Borkowski, Andrew W. (Author), Jackson, Walker S. (Author), Faas, Henryk (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Elsevier, 2010-05-19T17:20:22Z.
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