Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

Release of cell surface-bound ligands by A-Disintegrin-And-Metalloprotease (ADAM) transmembrane metalloproteases is essential for signalling by cytokine, cell adhesion, and tyrosine kinase receptors. For Eph receptor ligands, it provides the switch between cell-cell adhesion and repulsion. Ligand sh...

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Main Authors: Janes, Peter W. (Author), Wimmer-Kleikamp, Sabine H. (Author), Frangakis, Achilleas S. (Author), Treble, Kane (Author), Griensshaber, Bettina (Author), Sabet, Ola (Author), Grabenbauer, Markus (Author), Ting, Alice Y. (Contributor), Saftig, Paul (Author), Bastiaens, Philippe I. (Author), Lackmann, Martin (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-03-15T18:02:10Z.
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