Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

Background The understanding of regulatory and signaling networks has long been a core objective in Systems Biology. Knowledge about these networks is mainly of qualitative nature, which allows the construction of Boolean models, where the state of a component is either 'off' or 'on&#...

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Bibliographic Details
Main Authors: Wittmann, Dominik M. (Author), Krumsiek, Jan (Author), Saez-Rodriguez, Julio (Contributor), Lauffenburger, Douglas A. (Contributor), Klamt, Steffen (Author), Theis, Fabian J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd., 2010-03-04T19:51:46Z.
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