A multipathway phosphoproteomic signaling network model of idiosyncratic and inflammatory cytokine-induced toxicity in human hepatocytes
Idiosyncratic drug hepatotoxicity is a hepatotoxicity subset that occurs in a very small fraction of human patients, is poorly predicted by standard preclinical models and in clinical trials, and frequently leads to postapproval drug failure. Animal models utilizing bacterial LPS co-administration t...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Institute of Electrical and Electronics Engineers,
2010-03-04T18:44:46Z.
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| Subjects: | |
| Online Access: | Get fulltext |