The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases

The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases

IscB proteins are putative nucleases encoded in a distinct family of IS200/IS605 transposons and are likely ancestors of the RNA-guided endonuclease Cas9, but the functions of IscB and its interactions with any RNA remain uncharacterized. Using evolutionary analysis, RNA sequencing, and biochemical...

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Main Authors: Altae-Tran, Han (Author), Kannan, Soumya (Author), Demircioglu, F Esra (Author), Oshiro, Rachel (Author), Nety, Suchita P (Author), McKay, Luke J (Author), Dlakić, Mensur (Author), Inskeep, William P (Author), Makarova, Kira S (Author), Macrae, Rhiannon K (Author), Koonin, Eugene V (Author), Zhang, Feng (Author)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2022-04-25T17:24:22Z.
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