The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope

The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope

<jats:p>The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes. It is also possible, at least in theory, for proteostasis mechanisms that promote strict quality control to gr...

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Main Authors: Yoon, Jimin (Author), Nekongo, Emmanuel E (Author), Patrick, Jessica E (Author), Hui, Tiffani (Author), Phillips, Angela M (Author), Ponomarenko, Anna I (Author), Hendel, Samuel J (Author), Sebastian, Rebecca M (Author), Zhang, Yu Meng (Author), Butty, Vincent L (Author), Ogbunugafor, C Brandon (Author), Lin, Yu-Shan (Author), Shoulders, Matthew D (Author)
Format: Article
Language:English
Published: Public Library of Science (PLoS), 2022-03-18T18:58:36Z.
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