Automated Flow Synthesis of Peptide-PNA Conjugates

Automated Flow Synthesis of Peptide-PNA Conjugates

Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) covalently attached to PNAs may facilitate clinical development by improving uptake into cells. We report an efficie...

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Bibliographic Details
Main Authors: Li, Chengxi (Author), Callahan, Alex J (Author), Phadke, Kruttika S (Author), Bellaire, Bryan (Author), Farquhar, Charlotte E (Author), Zhang, Genwei (Author), Schissel, Carly K (Author), Mijalis, Alexander J (Author), Hartrampf, Nina (Author), Loas, Andrei (Author), Verhoeven, David E (Author), Pentelute, Bradley L (Author)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2022-03-15T19:07:21Z.
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