Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity. Here we report a 2.1-Å structure and the drug-binding site of E's transmembrane domain (ETM), determined using solid-state NMR spectroscopy. In...

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Bibliographic Details
Main Authors: Mandala, Venkata S (Author), McKay, Matthew J (Author), Shcherbakov, Alexander A (Author), Dregni, Aurelio J (Author), Kolocouris, Antonios (Author), Hong, Mei (Author)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2022-03-08T20:31:03Z.
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