Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias

Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias

Patients with myelodysplastic syndromes (MDSs) display severe anemia but the mechanisms underlying this phenotype are incompletely understood. Right open-reading-frame kinase 2 (RIOK2) encodes a protein kinase located at 5q15, a region frequently lost in patients with MDS del(5q). Here we show that...

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Main Authors: Raundhal, Mahesh (Author), Ghosh, Shrestha (Author), Myers, Samuel A (Author), Cuoco, Michael S (Author), Singer, Meromit (Author), Carr, Steven A (Author), Waikar, Sushrut S (Author), Bonventre, Joseph V (Author), Ritz, Jerome (Author), Stone, Richard M (Author), Steensma, David P (Author), Regev, Aviv (Author), Glimcher, Laurie H (Author)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2021-10-04T19:18:26Z.
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