Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus

Antibody paratopes are formed by hypervariable complementarity-determining regions (CDRH3s) and variable gene-encoded CDRs. The latter show biased usage in human broadly neutralizing antibodies (bnAbs) against both HIV and influenza virus, suggesting the existence of gene-endowed targeting solutions...

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Main Authors: Sangesland, Maya (Author), Ronsard, Larance (Author), Kazer, Samuel Weisgurt (Author), Bals, Julia (Author), Boyoglu-Barnum, Seyhan (Author), Yousif, Ashraf S. (Author), Barnes, Ralston (Author), Feldman, Jared (Author), Quirindongo-Crespo, Maricel (Author), McTamney, Patrick M. (Author), Rohrer, Daniel (Author), Lonberg, Nils (Author), Chackerian, Bryce (Author), Graham, Barney S. (Author), Kanekiyo, Masaru (Author), Shalek, Alexander K (Author), Lingwood, Daniel (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Broad Institute of MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-10-30T17:10:54Z.
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