A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood

A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood

B cell receptors (BCRs) display a combination of variable (V)-gene-encoded complementarity determining regions (CDRs) and adaptive/hypervariable CDR3 loops to engage antigens. It has long been proposed that the former tune for recognition of pathogens or groups of pathogens. To experimentally evalua...

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Main Authors: Sangesland, Maya (Author), Yousif, Ashraf S. (Author), Ronsard, Larance (Author), Kazer, Samuel Weisgurt (Author), Zhu, Alex Lee (Author), Gatter, G. James (Author), Hayward, Matthew R. (Author), Barnes, Ralston M. (Author), Quirindongo-Crespo, Maricel (Author), Rohrer, Daniel (Author), Lonberg, Nils (Author), Kwon, Douglas (Author), Shalek, Alexander K (Author), Lingwood, Daniel (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-10-27T21:47:55Z.
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