Minimal PAM specificity of a highly similar SpCas9 ortholog
RNA-guided DNA endonucleases of the CRISPR-Cas system are widely used for genome engineering and thus have numerous applications in a wide variety of fields. CRISPR endonucleases, however, require a specific protospacer adjacent motif (PAM) flanking the target site, thus constraining their targetabl...
| Main Authors: | , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS),
2020-08-25T19:18:58Z.
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| Subjects: | |
| Online Access: | Get fulltext |