Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Circulating tumor cells (CTCs) play a fundamental role in cancer progression. However, in mice, limited blood volume and the rarity of CTCs in the bloodstream preclude longitudinal, in-depth studies of these cells using existing liquid biopsy techniques. Here, we present an optofluidic system that c...

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Main Authors: Hamza, Bashar M. (Author), Ng, Sheng Rong (Author), Prakadan, Sanjay (Author), Delgado, Francisco Feijo (Author), Chin, Christopher R. (Author), King, Emily M. (Author), Yang, Lucy F. (Author), Davidson, Shawn Michael (Author), DeGouveia, Kelsey L. (Author), Cermak, Nathan (Author), Warren Navia, Andrew (Author), Winter, Peter S. (Author), Drake, Riley (Author), Tammela, Tuomas (Author), Li, Carman Man-Chung (Author), Papagiannakopoulos, Thales (Author), Gupta, Alejandro J. (Author), Shaw Bagnall, Josephine (Author), Knudsen, Scott (Author), Vander Heiden, Matthew G. (Author), Wasserman, Steven (Author), Jacks, Tyler E (Author), Shalek, Alexander K (Author), Manalis, Scott R (Author)
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2020-07-22T21:51:00Z.
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