Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies

Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies

Eukaryotic genes are regulated by multivalent transcription factor complexes. Through cooperative self-assembly, these complexes perform nonlinear regulatory operations involved in cellular decision-making and signal processing. In this study, we apply this design principle to synthetic networks, te...

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Bibliographic Details
Main Authors: Bashor, Caleb J. (Author), Patel, Nikit (Author), Choubey, Sandeep (Author), Beyzavi, Ali (Author), Kondev, Jané (Author), Collins, James J. (Author), Khalil, Ahmad S. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2020-07-22T18:25:40Z.
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