DNA phosphorothioate modification-a new multi-functional epigenetic system in bacteria

DNA phosphorothioate modification-a new multi-functional epigenetic system in bacteria

Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is replaced by a sulphur atom, share similar physical and chemical properties with phosphodiesters but confer enhanced nuclease tolerance on DNA/RNA, making PTs a valuable biochemical and pharmacological tool. In...

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Bibliographic Details
Main Authors: Wang, Lianrong (Author), Jiang, Susu (Author), Deng, Zixin (Author), Dedon, Peter C (Author), Chen, Shi (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Oxford University Press (OUP), 2020-07-21T18:38:50Z.
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