Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding
Most AAA+ remodeling motors denature proteins by pulling on the peptide termini of folded substrates, but it is not well-understood how motors produce grip when resisting a folded domain. Here, at single amino-acid resolution, we identify the determinants of grip by measuring how substrate tail sequ...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications, Ltd,
2020-07-13T18:39:48Z.
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| Subjects: | |
| Online Access: | Get fulltext |