Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix

Extracellular matrix (ECM) deposition is a hallmark of many diseases, including cancer and fibroses. To exploit the ECM as an imaging and therapeutic target, we developed alpaca-derived libraries of "nanobodies" against disease-associated ECM proteins. We describe here one such nanobody, N...

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Bibliographic Details
Main Authors: Jailkhani, Noor (Author), Ingram, Jessica R. (Author), Rashidian, Mohammad (Author), Rickelt, Steffen (Author), Tian, Chenxi (Author), Mak, Howard (Author), Jiang, Zhigang (Author), Ploegh, Hidde L. (Author), Hynes, Richard O (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2020-06-30T21:24:08Z.
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