CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data

CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data

Tiling screens that use CRISPR-Cas technologies provide a powerful approach for the mapping of regulatory elements to phenotypes of interest1-6. Here we present CRISPR screening uncharacterized region function (CRISPR-SURF), a deconvolution framework that can be used to identify functional regulator...

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Bibliographic Details
Main Authors: Hsu, Jonathan Y. (Author), Fulco, Charles P. (Author), Farouni, Rick (Author), Clement, Kendell (Author), Engreitz, Jesse Michael (Author), Lander, Eric Steven (Author), Pinello, Luca (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-21T19:12:31Z.
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