Genome-wide CRISPR screen for Zika virus resistance in human neural cells

Genome-wide CRISPR screen for Zika virus resistance in human neural cells

Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural cells. We identified ZIKV host genes in human pluripotent stem cell (hPSC)-der...

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Main Authors: Li, Yun (Author), Muffat, Julien (Author), Omer Javed, Attya (Author), Keys, Heather R. (Author), Lungjangwa, Tenzin (Author), Bosch, Irene (Author), Khan, Mehreen (Author), Virgilio, Maria C. (Author), Gehrke, Lee (Author), Sabatini, David M. (Author), Jaenisch, Rudolf (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences, 2020-05-07T13:32:10Z.
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