Increased PHGDH expression promotes aberrant melanin accumulation
Background: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods: In order to study the effect of increased PHGDH expression in tissues in vivo, we gener...
| Main Authors: | , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC,
2020-04-08T14:35:03Z.
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| Subjects: | |
| Online Access: | Get fulltext |