Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives

Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives

A unified enantioselective total synthesis and anticancer evaluation of all known epoxide-containing communesin alkaloids and related derivatives is described. Our synthesis is predicated on the convergent and modular diazene-directed assembly of two complex fragments to secure the critical C3a-C3a&...

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Bibliographic Details
Main Authors: Pompeo, Matthew M (Author), Cheah, Jaime H (Author), Movassaghi, Mohammad (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2019-09-25T20:34:28Z.
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