Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers

Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle proteins. We uncovered a distinct class of miRNAs that target...

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Main Authors: Hydbring, Per (Author), Wang, Yinan (Author), Fassl, Anne (Author), Li, Xiaoting (Author), Matia, Veronica (Author), Otto, Tobias (Author), Choi, Yoon Jong (Author), Sweeney, Katharine E. (Author), Suski, Jan M. (Author), Yin, Hao (Author), Bogorad, Roman (Author), Goel, Shom (Author), Yuzugullu, Haluk (Author), Kauffman, Kevin John (Author), Yang, Jung H (Author), Jin, Chong (Author), Li, Yingxiang (Author), Floris, Davide (Author), Swanson, Richard (Author), Ng, Kimmie (Author), Sicinska, Ewa (Author), Anders, Lars (Author), Zhao, Jean J. (Author), Polyak, Kornelia (Author), Anderson, Daniel Griffith (Author), Li, Cheng (Author), Sicinski, Piotr (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-08-13T15:08:29Z.
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