EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

Many cancer types are driven by oncogenic transcription factors that have been difficult to drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers. Through chemical genomics screening, we identified that Ewing sarcoma is a disease with preferential sensitivity to T...

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Main Authors: Iniguez, Amanda Balboni (Author), Stolte, Björn (Author), Wang, Emily Jue (Author), Conway, Amy Saur (Author), Alexe, Gabriela (Author), Dharia, Neekesh V. (Author), Kwiatkowski, Nicholas (Author), Zhang, Tinghu (Author), Abraham, Brian J. (Author), Mora, Jaume (Author), Kalev, Peter (Author), Leggett, Alan (Author), Chowdhury, Dipanjan (Author), Benes, Cyril H. (Author), Gray, Nathanael S. (Author), Stegmaier, Kimberly (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2019-03-26T17:10:19Z.
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