Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Triple-negative breast cancers (TNBC) are genetically characterized by aberrations in TP53 and a low rate of activating point mutations in common oncogenes, rendering it challenging in applying targeted therapies. We performed whole-exome sequencing (WES) and RNA sequencing (RNA-seq) to identify som...

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Bibliographic Details
Main Authors: Murphy, Charles J. (Author), Karreth, Florian A. (Author), Elemento, Olivier (Author), Toker, Alex (Author), Wulf, Gerburg M. (Author), Cantley, Lewis C. (Author), Yang, Kangkang (Author), Liu, Hui (Contributor), Emdal, Kristina Bennet (Contributor), Cantley, Lewis C (Contributor), White, Forest M. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), White, Forest M (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research (AACR), 2019-03-18T18:31:13Z.
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