Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6

Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6

Parkinson's disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in neuron...

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Main Authors: Nicholatos, Justin W (Author), Francisco, Adam B (Author), Bender, Carolyn A (Author), Yeh, Tiffany (Author), Lugay, Fraz J (Author), Salazar, Jairo E (Author), Libert, Sergiy (Author), Nicholatos, Justin W. (Author), Francisco, Adam B. (Author), Bender, Carolyn A. (Author), Lugay, Fraz J. (Author), Salazar, Jairo E. (Author), Glorioso, Christin A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2018-11-15T14:19:44Z.
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