Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics

Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics

RNA interference (RNAi) is a major, powerful platform for gene perturbations, but is restricted by off-target mechanisms. Communication between RNAs, small RNAs, and RNA-binding proteins (RBPs) is a pervasive feature of cellular RNA networks. We present a crosstalk scenario, designated as crosstalk...

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Bibliographic Details
Main Authors: Spengler, Ryan M. (Author), Grigelioniene, Giedre (Author), Kobayashi, Tatsuya (Author), Suzuki, Hiroshi (Contributor), Sharp, Phillip A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sharp, Phillip A (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-11-07T15:31:29Z.
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