Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking antibody against a single chemokine is expected to be insufficient for efficacy. Here we show single-chain antibodies can be engineered for broad crossreactivity toward multiple human and mouse proinflammato...

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Bibliographic Details
Main Authors: Miyabe, Yoshishige (Author), Miyabe, Chie (Author), Luster, Andrew D. (Author), Angelini, Alessandro (Contributor), Newsted, Daniel (Contributor), Kwan, Byron Hua (Contributor), Kelly, Ryan Lewis (Contributor), Jamy, Misha N. (Contributor), Wittrup, Karl Dane (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-11-02T20:42:53Z.
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