High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults

Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infection, since potent bnAbs develop with greater freque...

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Main Authors: Roider, Julia (Author), Maehara, Takashi (Author), Ngoepe, Abigail (Author), Ramsuran, Duran (Author), Muenchhoff, Maximilian (Author), Adland, Emily (Author), Jooste, Pieter (Author), Karim, Farina (Author), Kuhn, Warren (Author), Ndung'u, Thumbi (Author), Morris, Lynn (Author), Moore, Penny L. (Author), Kløverpris, Henrik (Author), Goulder, Philip (Author), Leslie, Alasdair (Author), Aicher, Toby Paul (Contributor), Kazer, Samuel Weisgurt (Contributor), Shalek, Alexander K (Contributor), Pillai, Shiv (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Frontiers Research Foundation, 2018-10-23T12:14:30Z.
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