Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

The gut microbiota modulate host biology in numerous ways, but little is known about the molecular mediators of these interactions. Previously, we found a widely distributed family of nonribosomal peptide synthetase gene clusters in gut bacteria. Here, by expressing a subset of these clusters in Esc...

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Main Authors: Guo, Chun-Jun (Author), Chang, Fang-Yuan (Contributor), Wyche, Thomas P. (Author), Backus, Keriann M. (Author), Acker, Timothy M. (Author), Funabashi, Masanori (Author), Taketani, Mao (Author), Donia, Mohamed S. (Author), Nayfach, Stephen (Author), Pollard, Katherine S. (Author), Craik, Charles S. (Author), Cravatt, Benjamin F. (Author), Clardy, Jon (Author), Voigt, Christopher A. (Contributor), Fischbach, Michael A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-09-12T17:52:03Z.
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