ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases. However, iPSCs generated from aged donors (A-iPSCs) exhibit higher genomic instability, defects in apoptosis an...

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Main Authors: Skamagki, Maria (Author), Correia, Cristina (Author), Yeung, Percy (Author), Baslan, Timour (Author), Beck, Samuel (Author), Zhang, Cheng (Author), Ross, Christian A (Author), Dang, Lam (Author), Liu, Zhong (Author), Giunta, Simona (Author), Chang, Tzu-Pei (Author), Wang, Joye (Author), Ananthanarayanan, Aparna (Author), Bohndorf, Martina (Author), Bosbach, Benedikt (Author), Adjaye, James (Author), Funabiki, Hironori (Author), Kim, Jonghwan (Author), Lowe, Scott (Author), Lu, Chi-Wei (Author), Li, Hu (Author), Zhao, Rui (Author), Kim, Kitai (Author), Collins, James J. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-08-28T16:09:32Z.
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