A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans

A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans

Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen. Here, we developed a CRISPR-Cas9-based 'gene drive array' platform to facilitate efficient genetic analysis in C. albicans. In our system, a mo...

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Bibliographic Details
Main Authors: Shapiro, Rebecca S. (Author), Chavez, Alejandro (Author), Porter, Caroline B. M. (Author), Hamblin, Meagan (Author), Kaas, Christian S. (Author), DiCarlo, James E. (Author), Zeng, Guisheng (Author), Xu, Xiaoli (Author), Revtovich, Alexey V. (Author), Kirienko, Natalia V. (Author), Wang, Yue (Author), Church, George M. (Author), Collins, James J. (Author)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-08-28T15:42:50Z.
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