Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Effective treatment for glioblastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver dual combination therapies. Using intravital...

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Bibliographic Details
Main Authors: Vu Han, Tu-Lan (Author), Balkanska-Sinclair, Elena (Author), Floyd, Scott R (Author), Lam, Fred Chiu-Lai (Contributor), Morton, Stephen Winford (Contributor), Wyckoff, Jeffrey (Contributor), Vu-H (Contributor), Hwang, Mun Kyung (Contributor), Maffa, Amanda (Contributor), Yaffe, Michael B (Contributor), Hammond, Paula T (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-13T16:22:43Z.
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