Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling via c-Myc. Mule also regulates protein levels o...

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Main Authors: Dominguez-Brauer, Carmen (Author), Hao, Zhenyue (Author), Elia, Andrew J (Author), Fortin, Jérôme M (Author), Nechanitzky, Robert (Author), Brauer, Patrick M (Author), Sheng, Yi (Author), Chio, Iok In Christine (Author), Haight, Jillian (Author), Pollett, Aaron (Author), Cairns, Robert (Author), Tworzyanski, Leanne (Author), Inoue, Satoshi (Author), Reardon, Colin (Author), Marques, Ana (Author), Silvester, Jennifer (Author), Cox, Maureen A (Author), Wakeham, Andrew (Author), van Es, Johan H (Author), Clevers, Hans (Author), Sato, Toshiro (Author), Mak, Tak W (Author), Mana, Miyeko (Contributor), Yilmaz, Omer (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-03T18:41:09Z.
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