RNF43 is frequently mutated in colorectal and endometrial cancers

RNF43 is frequently mutated in colorectal and endometrial cancers

We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with...

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Main Authors: Giannakis, Marios (Author), Hodis, Eran (Author), Jasmine Mu, Xinmeng (Author), Yamauchi, Mai (Author), Rosenbluh, Joseph (Author), Cibulskis, Kristian (Author), Saksena, Gordon (Author), Lawrence, Michael S (Author), Qian, Zhi Rong (Author), Nishihara, Reiko (Author), Van Allen, Eliezer M (Author), Hahn, William C (Author), Gabriel, Stacey B (Author), Getz, Gad (Author), Ogino, Shuji (Author), Fuchs, Charles S (Author), Garraway, Levi A (Author), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-06-28T19:52:10Z.
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