Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloi...

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Bibliographic Details
Main Authors: Yu, Haiyan (Author), Hughes, Nicholas W. (Author), Kendirli, Arek (Author), Klein, Klara (Author), Lander, Eric S. (Author), Wang, Tim (Contributor), Liu, Bingxu (Contributor), Chen, Walter W. (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-06-28T18:57:39Z.
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