A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Host proteins are essential for HIV entry and replication and can be important nonviral therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified nearly a thousand candidate host factors, but there is little agreement among studies and few factors have been validated. He...

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Main Authors: Park, Ryan J (Author), Koundakjian, Dylan (Author), Hultquist, Judd F (Author), Lamothe-Molina, Pedro (Author), Monel, Blandine (Author), Schumann, Kathrin (Author), Yu, Haiyan (Author), Krupzcak, Kevin M (Author), Garcia-Beltran, Wilfredo (Author), Piechocka-Trocha, Alicja (Author), Krogan, Nevan J (Author), Marson, Alexander (Author), Hacohen, Nir (Author), Walker, Bruce D (Author), Wang, Tim (Contributor), Sabatini, David (Contributor), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-06-28T18:42:57Z.
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