The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Expression of the MECOM (also known as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloid leukemia (AML) and is associated with poor clinical outcome. Here, through transcriptomic and metabolomic profiling of hematopoietic cells, we reveal that EVI1 over...

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Main Authors: Bassil, Christopher F (Author), Ben-Sahra, Issam (Author), Benajiba, Lina (Author), Alexe, Gabriela (Author), Pikman, Yana (Author), Conway, Amy S (Author), Burgess, Michael R (Author), Li, Qing (Author), Luciano, Frédéric (Author), Auberger, Patrick (Author), Galinsky, Ilene (Author), DeAngelo, Daniel J (Author), Stone, Richard M (Author), Zhang, Yi (Author), Perkins, Archibald S (Author), Shannon, Kevin (Author), Puissant, Alexandre (Author), Stegmaier, Kimberly (Author), Fenouille, Nina (Contributor), Ramos, Azucena (Contributor), Hemann, Michael (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-06-26T15:01:12Z.
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