Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung adenocarcinoma mouse models, including genetic models, we show that autochthonous tumors that lacked T cell infiltration...

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Bibliographic Details
Main Authors: Pfirschke, Christina (Author), Engblom, Camilla (Author), Rickelt, Steffen (Contributor), Cortez-Retamozo, Virna (Author), Garris, Christopher (Author), Pucci, Ferdinando (Author), Yamazaki, Takahiro (Author), Poirier-Colame, Vichnou (Author), Newton, Andita (Author), Redouane, Younes (Author), Lin, Yi-Jang (Author), Wojtkiewicz, Gregory (Author), Iwamoto, Yoshiko (Author), Mino-Kenudson, Mari (Author), Huynh, Tiffany G. (Author), Hynes, Richard O. (Contributor), Freeman, Gordon J. (Author), Kroemer, Guido (Author), Zitvogel, Laurence (Author), Weissleder, Ralph (Author), Pittet, Mikael J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-06-22T15:39:51Z.
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