Mechanism and timing of Mcm2-7 ring closure during DNA replication origin licensing
The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear. The origin-recognition complex (ORC), Cdc6 and Cdt1 facilitate this process by establishing a topological link betw...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature,
2018-06-21T13:50:39Z.
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| Subjects: | |
| Online Access: | Get fulltext |